Eradication of HIV-1 from CNS Reservoirs PDF Print E-mail
Written by Joseph Jeymohan   
Tuesday, 21 February 2012 20:17

Eradication of HIV-1 from CNS Reservoirs: Implications for Therapeutics

NIH-grantThe National Institute of Mental Health (NIMH), National Institute of Neurological Disorders and Stroke (NINDS), and National Institute of Allergy and Infectious Disease (NIAID) invite research grant applications to address the problem of HIV-1 persistence focused solely on the central nervous system (CNS) of HIV-infected persons treated with Highly Active Anti-Retroviral Therapy (HAART).



This Funding Opportunity Announcement (FOA) will support innovative research in five areas: 


(1) basic research to identify and characterize CNS-based cellular reservoirs of HIV-1 for individuals on HAART;


(2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of CNS-based HIV-1 reservoirs in relationship to the effects and timing of HAART, viral expression, and viral evolution within the brain; 


(3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective HAART;


(4) drug screening of potential agents which traverse the blood-brain barrier and eliminate latent or other sources of residual virus in the CNS;


and (5) design of therapeutic strategies aimed at eradication of HIV-1 from the CNS.  Applications ranging from basic to translational research in domestic and international settings are of interest. Multidisciplinary research teams are encouraged but not required

Jeymohan Joseph, PhD
Chief, HIV Pathogenesis, Neuropsychiatry and Treatment Branch
Division of AIDS Research
National Institute of Mental Health
Room 6219, MSC 9619
6001 Executive Boulevard
Bethesda, MD 20892
Telephone: 301-443-3012

Key words: HIV CNS, HIV Reservoirs NIH grant, HIV brain
Last Updated on Sunday, 04 March 2012 14:37


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