Unique Challenges and Opportunities for Eradication of CNS HIV Reservoirs
The Division of AIDS Research at the US National Institute of Mental Health is organizing a satellite meeting on December 6, 2011 prior to the opening of the "Fifth International Workshop on HIV Persistence during Therapy" at Westin St Maarten Dawn Beach Resort, St Maarten, West Indies.
HIV cure is a key priority area for NIH and NIAID recently awarded $14 million/year for research on eradication of HIV through the Martin Delaney Collaboratory.
A number of HIV eradication strategies are currently being developed. However for successful cure, it may be necessary to target HIV brain reservoirs.
This meeting will examine current approaches for eradication and their impact on brain HIV reservoirs.
Some of the approaches being developed may be detrimental for brain and CNS issues needs to be considered before initiating human trials. Unique strategies for eliminating CNS reservoirs will also be discussed.
This meeting will convene leading HIV researchers and NeuroAIDS experts to address unique challenges and opportunities for eradication of brain HIV-1 reservoirs.
Jeymohan Joseph, PhD
Chief, HIV Pathogenesis, Neuropsychiatry and Treatment Branch
Division of AIDS Research
National Institute of Mental Health
Room 6219, MSC 9619
6001 Executive Boulevard
Bethesda, MD 20892
3:00 – 3:05 PM
Jeymohan Joseph, NIMH, Bethesda, MD
3:05 – 3:15 PM
HIV Reservoirs and Sanctuary Sites: Overview
Alain Lafeuillade, Dept Infectious Diseases, General Hospital, Toulon, France
3:15 – 3:25 PM
Mechanism of HIV Persistence
Tae-Wook Chun, NIAID, NIH, Bethesda, MD, USA
3:25 – 3:35 PM
Current Strategies for Eradication of HIV
Steven Deeks, University of California, San Francisco, CA, USA
3:35 – 3:45 PM
Astrocytes as a significant CNS Reservoir for proviral HIV DNA
Melissa Churchill, Burnet Institute, Melbourne, Australia
3:45 – 3:55 PM
The Role of Macrophages/Microglia as a CNS reservoir
Mario Stevenson, University of Miami, Miami, FL, USA
3:55 PM – 4:05 PM
Novel Approaches for detection of low level persistent HIV in CNS
Sarah Palmer, Karolinska Institute, Stockholm, Sweden, USA
4:05 – 4:15 PM
Novel strategies for delivery of anti-retrovirals into the brain using nanoparticles
David Margolis, University of North Carolina-Chapel Hill, NC, USA
4:15 – 4:25 PM
Unique CNS Challenges for Current Eradication Strategies
Janice Clements, Johns Hopkins University, Baltimore, MD, USA
4:25 – 5:30 PM
Discussion of CNS Challenges and Targeted Approaches for HIV Eradication
Co-Chairs: Mario Stevenson, University of Miami, Miami, FL, USA
Avindra Nath, NINDS, Bethesda, MD, USA
You can download this program by using this link:
Download the agenda
Key words: HIV cure, HIV eradication, HIV reservoirs