SAMHD1 in Dendritic Cells and HIV PDF Print E-mail
Written by Alain Lafeuillade   
Sunday, 22 May 2011 09:40

A Fundamental Breakthrough

A protein that inhibits an early step of the HIV-1 life cycle in immune cells has been identified in a paper published online in Nature this week. The antiretroviral protein is pivotal to the fate of infection by HIV-1 in immune cells of the myeloid lineage

HIV-1 is unable to replicate efficiently in dendritic cells. Some lentiviruses, such as HIV-2 and simian immunodeficiency virus (SIV), produce a protein called Vpx that overcomes the block to replication, but the target of this protein has not been identified, until now. Monsef Benkirane and colleagues show that Vpx induces the degradation of a protein called SAMHD1. Reducing the expression of SAMHD1 in dendritic cells makes them more permissible to HIV replication.

These findings may be useful for the development of dendritic-cell-targeted vaccines against HIV/AIDS, the authors suggest.

CONTACT: Monsef Benkirane (Institut de Génétique Humaine and CNRS, Montpellier, France), Tel: +33 4 34 35 99 98


Key words: SAMHD1, dendritic cells, hiv
Last Updated on Sunday, 19 June 2011 08:27
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